Rice University and Texas Heart Institute: Damaged Hearts Rewired with Nanotube Fibers

Today we want to share the following press release from Rice University in order to shine a spotlight on a newly-published paper about an exciting medical application of carbon nanotube fibers! This work was done by a collection of researchers at Rice University and the Texas Heart Institute in Houston, the University of Illinois at Chicago, and the Città della Speranza Pediatric Research Institute in Padua, Italy. Rice alumnus Colin Young, one of the co-authors on the paper, is currently a member of the DexMat team!

Damaged hearts rewired with nanotube fibers

Texas Heart doctors confirm Rice-made, conductive carbon threads are electrical bridges

HOUSTON – (Aug. 13, 2019) – Thin, flexible fibers made of carbon nanotubes have now proven able to bridge damaged heart tissues and deliver the electrical signals needed to keep those hearts beating.

Scientists at Texas Heart Institute (THI) report they have used biocompatible fibers invented at Rice University in studies that showed sewing them directly into damaged tissue can restore electrical function to hearts.
Rice University Professor Matteo Pasquali, left, and Dr. Mehdi Razavi of the Texas Heart Institute check a thread of carbon nanotube fiber invented in Pasquali's Rice lab. They are collaborating on a method to use the fibers as electrical bridges to restore conductivity to damaged hearts. (Credit: Texas Heart Institute)

Rice Professor Matteo Pasquali, left, and Dr. Mehdi Razavi of the Texas Heart Institute check a thread of carbon nanotube fiber invented in Pasquali’s Rice lab. They are collaborating on a method to use the fibers as electrical bridges to restore conductivity to damaged hearts. Courtesy of the Texas Heart Institute

“Instead of shocking and defibrillating, we are actually correcting diseased conduction of the largest major pumping chamber of the heart by creating a bridge to bypass and conduct over a scarred area of a damaged heart,” said Dr. Mehdi Razavi, a cardiologist and director of Electrophysiology Clinical Research and Innovations at THI, who co-led the study with Rice chemical and biomolecular engineer Matteo Pasquali.

“Today there is no technology that treats the underlying cause of the No. 1 cause of sudden death, ventricular arrhythmias,” Razavi said. “These arrhythmias are caused by the disorganized firing of impulses from the heart’s lower chambers and are challenging to treat in patients after a heart attack or with scarred heart tissue due to such other conditions as congestive heart failure or dilated cardiomyopathy.”

Results of the studies on preclinical models appear as an open-access Editor’s Pick in the American Heart Association’s Circulation: Arrhythmia and Electrophysiology. The association helped fund the research with a 2015 grant.

The research springs from the pioneering 2013 invention by Pasquali’s lab of a method to make conductive fibers out of carbon nanotubes. The lab’s first threadlike fibers were a quarter of the width of a human hair, but contained tens of millions of microscopic nanotubes. The fibers are also being studied for electrical interfaces with the brain, for use in cochlear implants, as flexible antennas and for automotive and aerospace applications.

The experiments showed the nontoxic, polymer-coated fibers, with their ends stripped to serve as electrodes, were effective in restoring function during monthlong tests in large preclinical models as well as rodents, whether the initial conduction was slowed, severed or blocked, according to the researchers. The fibers served their purpose with or without the presence of a pacemaker, they found.
(Credit: James Philpot/Texas Heart Institute)

Illustration by James Philpot/Texas Heart Institute

In the rodents, they wrote, conduction disappeared when the fibers were removed.

“The reestablishment of cardiac conduction with carbon nanotube fibers has the potential to revolutionize therapy for cardiac electrical disturbances, one of the most common causes of death in the United States,” said co-lead author Mark McCauley, who carried out many of the experiments as a postdoctoral fellow at THI. He is now an assistant professor of clinical medicine at the University of Illinois College of Medicine.

“Our experiments provided the first scientific support for using a synthetic material-based treatment rather than a drug to treat the leading cause of sudden death in the U.S. and many developing countries around the world,” Razavi added.

Many questions remain before the procedure can move toward human testing, Pasquali said. The researchers must establish a way to sew the fibers in place using a minimally invasive catheter, and make sure the fibers are strong and flexible enough to serve a constantly beating heart over the long term. He said they must also determine how long and wide fibers should be, precisely how much electricity they need to carry and how they would perform in the growing hearts of young patients.
Researchers at Texas Heart Institute and Rice University have confirmed that flexible, conductive fibers made of carbon nanotubes can bridge damaged tissue to deliver electrical signals and keep hearts beating despite congestive heart failure or dilated cardiomyopathy or after a heart attack. (Credit: Texas Heart Institute)

Researchers at Texas Heart Institute and Rice University have confirmed that flexible, conductive fibers made of carbon nanotubes can bridge damaged tissue to deliver electrical signals and keep hearts beating despite congestive heart failure or dilated cardiomyopathy or after a heart attack. Courtesy of the Texas Heart Institute

“Flexibility is important because the heart is continuously pulsating and moving, so anything that’s attached to the heart’s surface is going to be deformed and flexed,” said Pasquali, who has appointments at Rice’s Brown School of Engineering and Wiess School of Natural Sciences.

“Good interfacial contact is also critical to pick up and deliver the electrical signal,” he said. “In the past, multiple materials had to be combined to attain both electrical conductivity and effective contacts. These fibers have both properties built in by design, which greatly simplifies device construction and lowers risks of long-term failure due to delamination of multiple layers or coatings.”

Razavi noted that while there are many effective antiarrhythmic drugs available, they are often contraindicated in patients after a heart attack. “What is really needed therapeutically is to increase conduction,” he said. “Carbon nanotube fibers have the conductive properties of metal but are flexible enough to allow us to navigate and deliver energy to a very specific area of a delicate, damaged heart.”

Rice alumna Flavia Vitale, now an assistant professor of neurology and of physical medicine and rehabilitation at the University of Pennsylvania, and Stephen Yan, a graduate student at Rice, are co-lead authors of the paper.

Co-authors are Colin Young and Julia Coco of Rice; Brian Greet of THI and Baylor St. Luke’s Medical Center; Marco Orecchioni and Lucia Delogu of the Città della Speranza Pediatric Research Institute, Padua, Italy; Abdelmotagaly Elgalad, Mathews John, Doris Taylor and Luiz Sampaio, all of THI; and Srikanth Perike of the University of Illinois at Chicago. Pasquali is the A.J. Hartsook Professor of Chemical and Biomolecular Engineering, a professor of materials science and nanoengineering and of chemistry.

The American Heart Association, the Welch Foundation, the Air Force Office of Scientific Research, the National Institutes of Health and Louis Magne supported the research.

Read the paper at https://www.ahajournals.org/doi/full/10.1161/CIRCEP.119.007256

This news release can also be found online at https://www.texasheart.org/news/ and https://news.rice.edu/2019/05/29/damaged-hearts-rewired-with-nanotube-fibers/

 

Source: Rice University News & Media

Flexible CNT Antennas from Rice U

Antennas of flexible nanotube films an alternative for electronics

HOUSTON – (June 10, 2019) – Antennas made of carbon nanotube films are just as efficient as copper for wireless applications, according to researchers at Rice University’s Brown School of Engineering. They’re also tougher, more flexible and can essentially be painted onto devices.

The Rice lab of chemical and biomolecular engineer Matteo Pasquali tested antennas made of “shear-aligned” nanotube films. The researchers discovered that not only were the conductive films able to match the performance of commonly used copper films, they could also be made thinner to better handle higher frequencies.

Metal-free antennas made of thin, strong, flexible carbon nanotube films are as efficient as common copper antennas, according to a new study by Rice University researchers. (Credit: Jeff Fitlow/Rice University)

Metal-free antennas made of thin, strong, flexible carbon nanotube films are as efficient as common copper antennas, according to a new study by Rice University researchers. (Credit: Jeff Fitlow/Rice University)

The results detailed in Applied Physics Letters advance the lab’s previous work on antennas based on carbon nanotube fibers.

The lab’s shear-aligned antennas were tested at the National Institute of Standards and Technology (NIST) facility in Boulder, Colorado, by lead author Amram Bengio, who carried out the research and wrote the paper while earning his doctorate in Pasquali’s lab. Bengio has since founded a company to further develop the material.

At the target frequencies of 5, 10 and 14 gigahertz, the antennas easily held their own with their metal counterparts, he said. “We were going up to frequencies that aren’t even used in Wi-Fi and Bluetooth networks today, but will be used in the upcoming 5G generation of antennas,” he said.

Bengio noted other researchers have argued nanotube-based antennas and their inherent properties have kept them from adhering to the “classical relationship between radiation efficiency and frequency,” but the Rice experiments with more refined films have proved them wrong, allowing for the one-to-one comparisons.

To make the films, the Rice lab dissolved nanotubes, most of them single-walled and up to 8 microns long, in an acid-based solution. When spread onto a surface, the shear force produced prompts the nanotubes to self-align, a phenomenon the Pasquali lab has applied in other studies.

Bengio said that although gas-phase deposition is widely employed as a batch process for trace deposition of metals, the fluid-phase processing method lends itself to more scalable, continuous antenna manufacturing.

The test films were about the size of a glass slide, and between 1 and 7 microns thick. The nanotubes are held together by strongly attractive van der Waals forces, which gives the material mechanical properties far better than those of copper.

The researchers said the new antennas could be suitable for 5G networks but also for aircraft, especially unmanned aerial vehicles, for which weight is a consideration; as wireless telemetry portals for downhole oil and gas exploration; and for future “internet of things” applications.

Rice University alumnus Amram Bengio holds a flexible nanotube film antenna. The antenna, which has proven as efficient as those made of copper wire, can essentially be painted onto devices. (Credit: Jeff Fitlow/Rice University)
Rice University alumnus Amram Bengio holds a flexible nanotube film antenna. The antenna, which has proven as efficient as those made of copper wire, can essentially be painted onto devices. (Credit: Jeff Fitlow/Rice University)

“There are limits because of the physics of how an electromagnetic wave propagates through space,” Bengio said. “We’re not changing anything in that regard. What we are changing is the fact that the material from which all these antennas will be made is substantially lighter, stronger and more resistant to a wider variety of adverse environmental conditions than copper.”

“This is a great example of how collaboration with national labs greatly expands the reach of university groups,” Pasquali said. “We could never have done this work without the intellectual involvement and experimental capabilities of the NIST team.”

Co-authors of the paper are Rice graduate student Lauren Taylor, research group manager Robert Headrick and alumni Michael King and Peiyu Chen; Damir Senic, Charles Little, John Ladbury, Christian Long, Christopher Holloway, Nathan Orloff and James Booth, all of NIST; and former Rice faculty member Aydin Babakhani, now an associate profess or of electrical and computer engineering at UCLA. Pasquali is the A.J. Hartsook Professor of Chemical and Biomolecular Engineering, professor of chemistry and of materials science and nanoengineering. Bengio is the founder and chief operating officer of Wootz, L.L.C.

The Air Force Office of Scientific Research, the Department of Defense and a National Defense Science and Engineering Graduate Fellowship supported the research.

 

Source: Rice University News & Media

DexMat at Interwire 2019

DexMat is at the Interwire 2019 expo in Atlanta, GA, to talk about our carbon nanotube yarns and films. If you are in the area from May 14 – May 16, come by booth 154 and say hello!

See DexMat at Interwire 2019

Come and meet DexMat at the Interwire Trade Exposition in Atlanta, GA from May 14th through May 16th!
We will be showing off examples of our Carbon Nanotube wires and films.

Learn more about Interwire at
 https://www.interwire19.com/

SBIR Funding Furthers DexMat CNT Technology

Source: Original article appears in the December 2018 issue of the Wire Journal International.
The feature on DexMat is on pages 48-50.

DexMat CNT Tape Shielded Cables Offer 50% Weight Reduction

Houston, TX- 12/11/2018. Working in collaboration with Minnesota Wire & Cable Company, DexMat has produced carbon nanotube (CNT) tape shielded RG-316 cables that perform comparably to copper (Cu) double braid shielded RG-316 cables. However, the CNT tape shields are 95% lighter than the copper double braid shields. The shielding effectiveness and insertion loss results for the CNT and Cu shielded cables are shown below. The CNT tape shielded cables have the following advantages:

  • Overall RG-316 cable weight reduction of CNT shielded vs. Cu double braid shielded cable without connectors is over 50%
  • CNT tape shield is 100 microns thick compared to 500 micron thick Cu double braid shield
  • Easy to apply CNT tape to coaxial as well as twisted pair type cables
  • Wide range of CNT tape widths and lengths are available for purchase
  • CNT tape shielded cables survive at least 1000 flex cycles with a minimum bend radius of at least 7.5X the jacketed cable diameter

Source: https://dexmat.com/cnt-products/cnt-tape-film/

Specification Sheet: DexMat fiber, tape, and cable specs Dec-2018

DexMat Named as SpaceCom Entrepreneur Challenge Semi-Finalist

HOUSTON – SpaceCom – The Space Commerce Conference and Exposition, where NASA, aerospace and industry come together to connect, announces the finalists of the SpaceCom Entrepreneur Challenge. Taking place at the George R. Brown Convention Center in Houston November 27-28, this challenge is the culmination of the SpaceCom Entrepreneur Summit (SES). The Entrepreneur Challenge began with 56 startup applicants. Through the first round of judging, that number was narrowed to 23 and now 17 semi-finalists who will present during the first day of the SpaceCom Entrepreneur Summit, Tuesday, November 27.

The semi-finalists include:

  • Arlula
  • Benchmark Space Systems
  • Cemvita Factory Inc.
  • Devali Inc
  • DexMat, Inc. 
  • EXOS Aerospace Systems & Technologies
  • Finsophy Inc.
  • Hedy-Anthiel Space Systems
  • Lazarus 3D Inc.,
  • Lucid Drone Technologies, Inc.
  • LunaSonde, LLC
  • Molon Labe LLC
  • SaraniaSat Inc.,
  • Solstar Space Company
  • STARK Industries LLC
  • Sugarhouse Aerospace
  • Swift Data LLC

At the culmination of day one, five finalists will be selected to present during a pitch competition. The winner will then be selected after the final round of pitches during the general session November 28 at 1:30 PM. During this presentation, members of the audience and a panel of judges will select the grand prize winner. These finalists are eligible to win the below prizes provided by Google Cloud for Startups:

  •  $100,000 in Google Cloud credits to the competition winner
  • $20,000 in Google Cloud credits for runners up
  • $3,000 in Google Cloud credits for every qualified entrant in the competition

Additional prizes include:

  • Guaranteed extended meeting with an investment firm
  • Speaking role at SpaceCom 2019
  • A booth at SpaceCom 2019

Source: https://spacecomexpo.com/wp-content/uploads/2018/11/SES-Finalists-Press-Release.final_.pdf

DexMat Featured in Wire Journal International

Source: Original article appears in the October 2018 issue of the Wire Journal International.
Free subscription is required to read the digital version of the article. The feature on DexMat is on pages 52-53.

Badminton Racket Strung with CNT Yarn [Demo]

This is no ordinary badminton racket! The strings are made entirely out of DexMat CNT yarn, offering superior performance, durability, and the ability to embed sensors and electronics directly into the rackets of the future because these CNT strings have high electrical conductivity. 700 micron diameter braided CNT yarn was used for the strings on this racket to match the typical diameter of polymer-based strings used in badminton rackets. Check out the video of the racket in action below:

 

DexMat Awarded Phase I SBIR: Robust Lightweight CNT Wiring for Space Systems


Abstract: 
NASA is challenged to find ways of effectively shielding sensitive electronic equipment from electromagnetic interference (EMI) without adding significant weight to space flight vehicles and satellites (the heavier they are the more fuel they need to achieve orbit).  EMI shielding for wire and cables is an attractive opportunity for weight reduction. However, with the advent of highly reusable next generation space vehicles, wiring must be not only light weight, but also strong and robust, capable of withstanding extreme conditions, intense vibration and long lifecycles. It is important that wire weight reductions do not come at the expense of mechanical strength or EMI shielding effectiveness.  DexMat is developing a novel and highly conductive Carbon nanotube (CNT) EMI shield product that will allow for significant weight reduction without compromising mechanical strength or shield effectiveness. CNTs are advancing as the most promising solution for reducing the weight of spacecraft wires.  The shielding effectiveness of CNT materials is comparable to that of heavy metal braids, but at a fraction of the weight.  Compared to a copper wire with the same diameter, a CNT fiber has 6 times higher strength, more than 6 times lower density,  and at least 25 times higher flexure tolerance, essential qualities for conductors in aerospace applications. Under this Phase I project, DexMat will develop CNT shielding braid (made from CNT yarn from Dexmat) that can potentially increase the mechanical strength of CNT tape used as a primary EMI shield. These CNT braids will be of different thicknesses and area coverage, to augment the performance and product appeal of CNT tapes. Additionally, DexMat will begin to conduct the first accelerated aging tests to determine the impact on mechanical strength of shielding made with CNT tapes, CNT yard braids, and hybrid CNT tape/braid combinations.

Potential NASA Applications: 
The first planned product to contain DexMat technology is lightweight CNT cables. CNT cables combine high strength, electrical and thermal conductivity with low density, making them ideal for aerospace applications where weight reduction is a priority, including reusable next generation space vehicles and satellites. Given the tremendous costs associated with satellite launches, NASA and the aerospace industry will see substantial savings from our CNT-based wire.

Potential Non-NASA Applications: 
DexMat CNT technology has applications in the military aircraft and commercial aviation markets, to effectively reduce weight of aircraft and satellite designs.  For a single-aisle aircraft, a 1% reduction of in weight can lead to a net cost savings of $240K-$1.6M per year in use. For larger aircraft, the savings can reach $2.4-5M. Additional applications include wearable electronics, eTextiles and bioelectronics.